Bioinformatics Database

The Wnt signaling pathway is an important regulator of skeletal development. Studies by Ei Hsu Hlaing et al,. (2020) showed that orthodontic tooth movement significantly stimulated the Wnt1 expression in both the PDL and alveolar osteocytes. The overall study suggest that Wnt1 signaling plays a vital role in tooth movement-initiated bone remodeling via innovative mechanotransduction approaches (Ei Hsu Hlaing et al,.2020). Wnt signaling also plays a central role in determining the fate of epithelial and neural crest progenitor cells by modulating the expression of mitogene such as BMP during embryogenesis. In a study, Wnt1 and Wnt3a double null mutation resulted in general decrease of all neural crest, particularly in the late-migrating neural crest cell population, thus demonstrating the importance of Wnt signaling in the expansion of the neural crest population (Ikeya et al., 1997).