Bioinformatics Database
TNFSF11: TNF superfamily member 11
Cellular Process
Tooth Eruption
Gene Name
TNFSF11: TNF superfamily member 11
Gene ID
8600
Gene Sequence
General Description
This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts.
Alternative titles; symbols
OSTEOPROTEGERIN LIGAND; OPGL RECEPTOR ACTIVATOR OF NF-KAPPA-B LIGAND; RANKL TNF-RELATED ACTIVATION-INDUCED CYTOKINE; TRANCE OSTEOCLAST DIFFERENTIATION FACTOR; ODF
Chromosome
Chromosome 13
Cytogenetic location
13q14.11
Encoded Protein
Tumor Necrosis Factor Ligand superfamily member 11 isoform 1
Function of the protein in oral and tooth development
Uribe et al., (2018) studied the expression of bone-regulatory factors expressed by human dental follicles and to compare the stimulated expression of tumour necrosis factor (ligand) superfamily, member 11/tumour necrosis factor receptor superfamily, member 11b (RANKL/OPG) in human dental follicle cells (HDFCs) from different patients. The authors demonstrated that RANKL expression is significantly higher in the coronal part of follicles than in the apical part (Uribe et al., 2018).
Bone resorption and remodeling is controlled by the function of osteoclasts. These processes involve signals induced by osteoprotegerin ligand (OPGL), a member of tumor necrosis factor (TNF) superfamily, and its cognate receptor RANK. Lomaga et al., (1999) reported that mice deficient in TNF receptor-associated factor 6 (TRAF6) are osteopetrotic with defects in tooth eruption due to impaired osteoclast function.
Dental and Oral Diseases
Protein Sequence
>NP_003692.1 tumor necrosis factor ligand superfamily member 11 isoform 1 [Homo sapiens]
MRRASRDYTKYLRGSEEMGGGPGAPHEGPLHAPPPPAPHQPPAASRSMFVALLGLGLGQVVCSVALFFYF
RAQMDPNRISEDGTHCIYRILRLHENADFQDTTLESQDTKLIPDSCRRIKQAFQGAVQKELQHIVGSQHI
RAEKAMVDGSWLDLAKRSKLEAQPFAHLTINATDIPSGSHKVSLSSWYHDRGWAKISNMTFSNGKLIVNQ
DGFYYLYANICFRHHETSGDLATEYLQLMVYVTKTSIKIPSSHTLMKGGSTKYWSGNSEFHFYSINVGGF
FKLRSGEEISIEVSNPSLLDPDQDATYFGAFKVRDID
Mutations
Related Literature
Uribe et al., (2018). https://doi.org/10.1111/eos.12568
Lomaga et al., (1999). https://doi.org/10.1101/gad.13.8.1015