Bioinformatics Database
TCIRG1: T cell immune regulator 1, ATPase H+ transporting V0 subunit a3
3D Protein Structure Viewer
Cellular Process
Tooth Eruption
Gene Name
TCIRG1: T cell immune regulator 1, ATPase H+ transporting V0 subunit a3
Gene ID
10312
Gene Sequence
General Description
This gene encodes a subunit of a large protein complex known as a vacuolar H+-ATPase (V-ATPase). The protein complex acts as a pump to move protons across the membrane. This movement of protons helps regulate the pH of cells and their surrounding environment. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis.
Alternative titles; symbols
ATPase, H+ TRANSPORTING, LYSOSOMAL, V0 SUBUNIT A3; ATP6V0A3 VACUOLAR PROTON PUMP, ALPHA SUBUNIT 3
Chromosome
Chromosome 11
Cytogenetic location
11q13.2
Encoded Protein
V-type proton ATPase 116 kDa subunit a3 isoform a
Function of the protein in oral and tooth development
v-H-ATPase is proposed to act as proton pump to acidify the enamel space, required to complete enamel mineralization. Research on mouse by Bronckers et al., (2012) reported that Tcirg1, which is essential for osteoclasts to pump protons into the bone, is not appreciably expressed in maturation stage of ameloblasts. The authors also suggested that a v-H-ATPase is potentially involved in intracellular acidification (Bronckers et al., 2012).
Dental and Oral Diseases
Protein Sequence
>NP_006010.2 V-type proton ATPase 116 kDa subunit a 3 isoform a [Homo sapiens]
MGSMFRSEEVALVQLFLPTAAAYTCVSRLGELGLVEFRDLNASVSAFQRRFVVDVRRCEELEKTFTFLQE
EVRRAGLVLPPPKGRLPAPPPRDLLRIQEETERLAQELRDVRGNQQALRAQLHQLQLHAAVLRQGHEPQL
AAAHTDGASERTPLLQAPGGPHQDLRVNFVAGAVEPHKAPALERLLWRACRGFLIASFRELEQPLEHPVT
GEPATWMTFLISYWGEQIGQKIRKITDCFHCHVFPFLQQEEARLGALQQLQQQSQELQEVLGETERFLSQ
VLGRVLQLLPPGQVQVHKMKAVYLALNQCSVSTTHKCLIAEAWCSVRDLPALQEALRDSSMEEGVSAVAH
RIPCRDMPPTLIRTNRFTASFQGIVDAYGVGRYQEVNPAPYTIITFPFLFAVMFGDVGHGLLMFLFALAM
VLAENRPAVKAAQNEIWQTFFRGRYLLLLMGLFSIYTGFIYNECFSRATSIFPSGWSVAAMANQSGWSDA
FLAQHTMLTLDPNVTGVFLGPYPFGIDPIWSLAANHLSFLNSFKMKMSVILGVVHMAFGVVLGVFNHVHF
GQRHRLLLETLPELTFLLGLFGYLVFLVIYKWLCVWAARAASAPSILIHFINMFLFSHSPSNRLLYPRQE
VVQATLVVLALAMVPILLLGTPLHLLHRHRRRLRRRPADRQEENKAGLLDLPDASVNGWSSDEEKAGGLD
DEEEAELVPSEVLMHQAIHTIEFCLGCVSNTASYLRLWALSLAHAQLSEVLWAMVMRIGLGLGREVGVAA
VVLVPIFAAFAVMTVAILLVMEGLSAFLHALRLHWVEFQNKFYSGTGYKLSPFTFAATDD
Mutations
Related Literature
Bronckers et al., (2012). https://doi.org/10.1016/j.bone.2011.12.019
