Bioinformatics Database
STIM1: Stromal interaction molecule 1
3D Protein Structure Viewer
Cellular Process
Enamel formation
Gene Name
STIM1: Stromal interaction molecule 1
Gene ID
6786
Gene Sequence
General Description
This gene encodes a type 1 transmembrane protein that mediates Ca2+ influx after depletion of intracellular Ca2+ stores by gating of store-operated Ca2+ influx channels (SOCs). It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region.
Alternative titles; symbols
Chromosome
Chromosome 11
Cytogenetic location
11p15.4
Encoded Protein
Stromal interaction molecule 1 isoform 5 precursor
Function of the protein in oral and tooth development
In developing mouse teeth at day 11, Wang et al. (2014) found expression of the Stim1 gene in maturation-stage ameloblasts, but not in secretory ameloblasts. Furukawa et al., (2017) generated mice with ectodermal tissue-specific deletion of Stim1, Stim2, and Stim1 and Stim2, and analyzed their enamel phenotypes as compared with those of control animals. In results showed ablation of Stim1 and Stim1/2 but not Stim2 expression resulted in chalky enamel and severe attrition at the incisor tips and molar cusps (Furukawa et al., 2017).
Dental and Oral Diseases
Protein Sequence
>NP_001369496.1 stromal interaction molecule 1 isoform 5 precursor [Homo sapiens]
MDVCVRLALWLLWGLLLHQGQSLSHSHSEKATGTSSGANSEESTAAEFCRIDKPLCHSEDEKLSFEAVRN
IHKLMDDDANGDVDVEESDEFLREDLNYHDPTVKHSTFHGEDKLISVEDLWKAWKSSEVYNWTVDEVVQW
LITYVELPQYEETFRKLQLSGHAMPRLAVTNTTMTGTVLKMTDRSHRQKLQLKALDTVLFGPPLLTRHNH
LKDFMLVVSIVIGVGGCWFAYIQNRYSKEHMKKMMKDLEGLHRAEQSLHDLQERLHKAQEEHRTVEVEKV
HLEKKLRDEINLAKQEAQRLKELREGTENERSRQKYAEEELEQVREALRKAEKELESHSSWYAPEALQKW
LQLTHEVEVQYYNIKKQNAEKQLLVAKEGAEKIKKKRNTLFGTFHVAHSSSLDDVDHKILTAKQALSEVT
AALRERLHRWQQIEILCGFQIVNNPGIHSLVAALNIDPSWMGSTRPNPAHFIMTDDVDDMDEEIVSPLSM
QYAAWLMGRRFSDRSLCSTSAGSDDQSLWKYPAPSLQSSVRQRLTEPQHGLGSQRDLTHSDSESSLHMSD
RQRVAPKPPQMSRAADEALNAMTSNGSHRLIEGVHPGSLVEKLPDSPALAKKALLALNHGLDKAHSLMEL
SPSAPPGGSPHLDSSRSHSPSSPDPDTPSPVGDSRALQASRNTRIPHLAGKKAVAEEDNGSIGEETDSSP
GRKKFPLKIFKKPLKK
Mutations
Related Literature
Wang et al.,(2014): https://doi.org/10.1177/0022034514527971
Furukawa et al., (2017): https://doi.org/10.1177/0022034517719872