Bioinformatics Database
SP6: Sp6 transcription factor
3D Protein Structure Viewer
Cellular Process
Enamel formation
Gene Name
SP6: Sp6 transcription factor
Gene ID
80320
Gene Sequence
General Description
SP6 belongs to a family of transcription factors that contain 3 classical zinc finger DNA-binding domains consisting of a zinc atom tetrahedrally coordinated by 2 cysteines and 2 histidines (C2H2 motif). These transcription factors bind to GC-rich sequences and related GT and CACCC boxes.
Alternative titles; symbols
KRUPPEL-LIKE FACTOR 14; KLF14 EPIPROFIN; EPFN
Chromosome
Chromosome 17
Cytogenetic location
17q21.32
Encoded Protein
Transcription factor Sp6 isoform X1
Function of the protein in oral and tooth development
Nakamura et al. (2004) determined that endogenous epiprofin expressed by primary mouse dental epithelial cells and epiprofin expressed by transfected COS-7 cells promoted cell proliferation. Transfection of an N-terminally truncated vector containing only the zinc finger domain resulted in no activity.
Dental and Oral Diseases
Protein Sequence
>XP_006722178.1 transcription factor Sp6 isoform X1 [Homo sapiens]
MLTAVCGSLGSQHTEAPHASPPRLDLQPLQTYQGHTSPEAGDYPSPLQPGELQSLPLGPEVDFSQGYELP
GASSRVTCEDLESDSPLAPGPFSKLLQPDMSHHYESWFRPTHPGAEDGSWWDLHPGTSWMDLPHTQGALT
SPGHPGALQAGLGGYVGDHQLCAPPPHPHAHHLLPAAGGQHLLGPPDGAKALEVAAPESQGLDSSLDGAA
RPKGSRRSVPRSSGQTVCRCPNCLEAERLGAPCGPDGGKKKHLHNCHIPGCGKAYAKTSHLKAHLRWHSG
DRPFVCNWLFCGKRFTRSDELQRHLQTHTGTKKFPCAVCSRVFMRSDHLAKHMKTHEGAKEEAAGAASGE
GKAGGAVEPPGGKGKREAEGSVAPSN
Mutations
Related Literature
Nakamura et al., (2004): https://doi.org/10.1074/jbc.M307502200
