Bioinformatics Database

SLC4A2: Solute carrier family 4 member 2

SLC4A2: Solute carrier family 4 member 2
3D Protein Structure Viewer​
Cellular Process
Enamel formation
Gene Name
SLC4A2: Solute carrier family 4 member 2
Gene ID
6522
General Description
This gene encodes a member of the anion exchanger family of membrane transport proteins. The encoded protein regulates intracellular pH, biliary bicarbonate secretion, and chloride uptake. Reduced expression of this gene may be associated with primary biliary cirrhosis (PBC) in human patients, while differential expression of this gene may be associated with malignant hepatocellular carcinoma, colon and gastric cancers.
Alternative titles; symbols
ANION EXCHANGER, NONERYTHROID; AE2 ERYTHROCYTE MEMBRANE PROTEIN BAND 3-LIKE 1; EPB3L1 BAND 3-LIKE PROTEIN; BND3L NONERYTHROID BAND 3; NBND3 HKB3
Chromosome
Chromosome 7
Cytogenetic location
7q36.1
Encoded Protein

Anion exchange protein 2 isoform 1

https://www.ncbi.nlm.nih.gov/protein/NP_003031.3/

Function of the protein in oral and tooth development

During enamel maturation, hydroxyapatite crystallites expand in volume, releasing protons that acidify the developing enamel. This acidity is neutralized by the buffering activity of carbonic anhydrases and ion transporters. Less hydroxyapatite forms in matrix metalloproteinase-20 null (Mmp20(-/-)) mouse incisors. Tye et al., (2010) investigated if ion regulation was altered in Mmp20(-/-) mouse enamel. The researchers stained the incisor of the wild-type and Mmp20(-/-) mice with pH indicators and found that wild-type mice had pronounced changes in enamel pH as development progressed. These pH changes were greatly reduced in Mmp20(-/-) mice (Tye et al, 2010). Expression of 4 ion-regulatory genes-Atp2b4, Slc4a2, Car6, Cftr was significantly decreased in enamel organs from Mmp20(-/-) mice (Tye et al, 2010).

Dental and Oral Diseases
Protein Sequence
>NP_003031.3 anion exchange protein 2 isoform 1 [Homo sapiens]
MSSAPRRPAKGADSFCTPEPESLGPGTPGFPEQEEDELHRTLGVERFEEILQEAGSRGGEEPGRSYGEED
FEYHRQSSHHIHHPLSTHLPPDARRRKTPQGPGRKPRRRPGASPTGETPTIEEGEEDEDEASEAEGARAL
TQPSPVSTPSSVQFFLQEDDSADRKAERTSPSSPAPLPHQEATPRASKGAQAGTQVEEAEAEAVAVASGT
AGGDDGGASGRPLPKAQPGHRSYNLQERRRIGSMTGAEQALLPRVPTDEIEAQTLATADLDLMKSHRFED
VPGVRRHLVRKNAKGSTQSGREGREPGPTPRARPRAPHKPHEVFVELNELLLDKNQEPQWRETARWIKFE
EDVEEETERWGKPHVASLSFRSLLELRRTLAHGAVLLDLDQQTLPGVAHQVVEQMVISDQIKAEDRANVL
RALLLKHSHPSDEKDFSFPRNISAGSLGSLLGHHHGQGAESDPHVTEPLMGGVPETRLEVERERELPPPA
PPAGITRSKSKHELKLLEKIPENAEATVVLVGCVEFLSRPTMAFVRLREAVELDAVLEVPVPVRFLFLLL
GPSSANMDYHEIGRSISTLMSDKQFHEAAYLADEREDLLTAINAFLDCSVVLPPSEVQGEELLRSVAHFQ
RQMLKKREEQGRLLPTGAGLEPKSAQDKALLQMVEAAGAAEDDPLRRTGRPFGGLIRDVRRRYPHYLSDF
RDALDPQCLAAVIFIYFAALSPAITFGGLLGEKTQDLIGVSELIMSTALQGVVFCLLGAQPLLVIGFSGP
LLVFEEAFFSFCSSNHLEYLVGRVWIGFWLVFLALLMVALEGSFLVRFVSRFTQEIFAFLISLIFIYETF
YKLVKIFQEHPLHGCSASNSSEVDGGENMTWAGARPTLGPGNRSLAGQSGQGKPRGQPNTALLSLVLMAG
TFFIAFFLRKFKNSRFFPGRIRRVIGDFGVPIAILIMVLVDYSIEDTYTQKLSVPSGFSVTAPEKRGWVI
NPLGEKSPFPVWMMVASLLPAILVFILIFMETQITTLIISKKERMLQKGSGFHLDLLLIVAMGGICALFG
LPWLAAATVRSVTHANALTVMSKAVAPGDKPKIQEVKEQRVTGLLVALLVGLSIVIGDLLRQIPLAVLFG
IFLYMGVTSLNGIQFYERLHLLLMPPKHHPDVTYVKKVRTLRMHLFTALQLLCLALLWAVMSTAASLAFP
FILILTVPLRMVVLTRIFTDREMKCLDANEAEPVFDEREGVDEYNEMPMPV
Mutations