Bioinformatics Database
SLC34A1: Solute carrier family 34 member 1
3D Protein Structure Viewer
Cellular Process
Dentin formation
Gene Name
SLC34A1: Solute carrier family 34 member 1
Gene ID
6569
Gene Sequence
General Description
This gene encodes a member of the type II sodium-phosphate cotransporter family. Mutations in this gene are associated with hypophosphatemia nephrolithiasis/osteoporosis 1. Alternative splicing results in multiple transcript variants.
Alternative titles; symbols
SOLUTE CARRIER FAMILY 17, MEMBER 2, FORMERLY; SLC17A2, FORMERLY SODIUM/PHOSPHATE TRANSPORT 2, KIDNEY; NPT2 RENAL SODIUM/PHOSPHATE TRANSPORT PROTEIN 2 NaPi3
Chromosome
Chromosome 5
Cytogenetic location
5q35.3
Encoded Protein
Sodium-dependent phosphate transport protein 2A isoform 1
Function of the protein in oral and tooth development
SLC34A1 is a phosphate Pi transporter. Phosphate (Pi) as an essential component of hydroxyapatite crystals. Studies suggest a key role for membrane proteins controlling Pi uptake during mineralization in the tooth (Merametdjian et al, 2018; Millán, 2013).
Dental and Oral Diseases
Protein Sequence
>NP_003043.3 sodium-dependent phosphate transport protein 2A isoform 1 [Homo sapiens]
MLSYGERLGSPAVSPLPVRGGHVMRGTAFAYVPSPQVLHRIPGTSAYAFPSLGPVALAEHTCPCGEVLER
HEPLPAKLALEEEQKPESRLVPKLRQAGAMLLKVPLMLTFLYLFVCSLDMLSSAFQLAGGKVAGDIFKDN
AILSNPVAGLVVGILVTVLVQSSSTSTSIIVSMVSSGLLEVSSAIPIIMGSNIGTSVTNTIVALMQAGDR
TDFRRAFAGATVHDCFNWLSVLVLLPLEAATGYLHHITRLVVASFNIHGGRDAPDLLKIITEPFTKLIIQ
LDESVITSIATGDESLRNHSLIQIWCHPDSLQAPTSMSRAEANSSQTLGNATMEKCNHIFVDTGLPDLAV
GLILLAGSLVLLCTCLILLVKMLNSLLKGQVAKVIQKVINTDFPAPFTWVTGYFAMVVGASMTFVVQSSS
VFTSAITPLIGLGVISIERAYPLTLGSNIGTTTTAILAALASPREKLSSAFQIALCHFFFNISGILLWYP
VPCTRLPIRMAKALGKRTAKYRWFAVLYLLVCFLLLPSLVFGISMAGWQVMVGVGTPFGALLAFVVLINV
LQSRSPGHLPKWLQTWDFLPRWMHSLKPLDHLITRATLCCARPEPRSPPLPPRVFLEELPPATPSPRLAL
PAHHNATRL
Mutations
Related Literature
Merametdjian et al., (2018): https://doi.org/10.1177/0022034517729811
Millán (2013): https://doi.org/10.1007/s00223-012-9672-8
