Bioinformatics Database

SERPINE1: Serpin family E member 1

SERPINE1: Serpin family E member 1
3D Protein Structure Viewer​
Cellular Process
Dentin formation
Gene Name
SERPINE1: Serpin family E member 1
Gene ID
5054
General Description
This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. The protein also functions as a component of innate antiviral immunity. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia.
Alternative titles; symbols
PLASMINOGEN ACTIVATOR INHIBITOR 1; PAI1 ENDOTHELIAL PLASMINOGEN ACTIVATOR INHIBITOR
Chromosome
Chromosome 7
Cytogenetic location
7q22.1
Encoded Protein

Plasminogen activator inhibitor 1 isoform 2 precursor

https://www.ncbi.nlm.nih.gov/protein/NP_000593.1/

Function of the protein in oral and tooth development

According to Jin et al., (2015), plasminogen activator inhibitor type 1 (PAI-1) plays important roles in many physiological processes like fibrotic disorders, metabolic disorders, and cancer. PAI-1 is expressed by bone cells and their substrates and present in bone matrix, known to be a regulator of bone remodeling. Studies indicate that PAI-1 contributes to hard tissue formation. In their studies, Jin et al., (2015) showed that recombinant human plasminogen activator inhibitor-1 (rhPAI-1) play a key role in cementogenic differentiation of human periodontal ligament stem cells (hPDLSCs).

Dental and Oral Diseases
Protein Sequence
>NP_000593.1 plasminogen activator inhibitor 1 isoform 2 precursor [Homo sapiens]
MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPYGVASVLAMLQ
LTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAIFVQRDLKLVQGFMPHFFRLF
RSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAVDQLTRLVLVNALYFNGQWKTPFPDSSTHRR
LFHKSDGSTVSVPMMAQTNKFNYTEFTTPDGHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQ
LISHWKGNMTRLPRLLVLPKFSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIE
VNESGTVASSSTAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP
Mutations
Related Literature