Bioinformatics Database
SDC1: Syndecan 1

3D Protein Structure Viewer
Cellular Process
Bud stage of tooth development
Gene Name
SDC1: Syndecan 1
Gene ID
6382
Gene Sequence
General Description
The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types.
Alternative titles; symbols
SYND1, SYNDECAN, SDC, CD138 ANTIGEN, CD138
Chromosome
Chromosome 2
Cytogenetic location
2p24.1
Encoded Protein
Syndecan-1 precursor
Function of the protein in oral and tooth development
In dental organs, syndecan-1 expression in mesenchymal tissues of tooth germ, including the dental papilla and dental follicles, has been reported. From in situ hybridization study Vainio et al, (1991) found that Syndecan RNA became accumulated in the condensing mesenchymal cells around the invaginating epithelial tooth bud during early development. This accumulation became more intense when morphogenesis advanced to the cap stage. During the bell stage, when the cuspal pattern of the tooth is established, syndecan transcripts were lost, and RNA was not detected in the terminally differentiated or postmitotic odontoblasts.
Dental and Oral Diseases
Protein Sequence
>NP_002988.4 syndecan-1 precursor [Homo sapiens]
MRRAALWLWLCALALSLQPALPQIVATNLPPEDQDGSGDDSDNFSGSGAGALQDITLSQQTPSTWKDTQL
LTAIPTSPEPTGLEATAASTSTLPAGEGPKEGEAVVLPEVEPGLTAREQEATPRPRETTQLPTTHLASTT
TATTAQEPATSHPHRDMQPGHHETSTPAGPSQADLHTPHTEDGGPSATERAAEDGASSQLPAAEGSGEQD
FTFETSGENTAVVAVEPDRRNQSPVDQGATGASQGLLDRKEVLGGVIAGGLVGLIFAVCLVGFMLYRMKK
KDEGSYSLEEPKQANGGAYQKPTKQEEFYA
Mutations
Related Literature
Vainio et al, (1991).