Bioinformatics Database
RELT: RELT TNF receptor
3D Protein Structure Viewer
Cellular Process
Enamel formation
Gene Name
RELT: RELT TNF receptor
Gene ID
84957
Gene Sequence
General Description
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is especially abundant in hematologic tissues. It has been shown to activate the NF-kappaB pathway and selectively bind TNF receptor-associated factor 1 (TRAF1). This receptor is capable of stimulating T-cell proliferation in the presence of CD3 signaling, which suggests its regulatory role in immune response.
Alternative titles; symbols
TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY, MEMBER 19-LIKE; TNFRSF19L
Chromosome
Chromosome 11
Cytogenetic location
11q13.4
Encoded Protein
Tumor necrosis factor receptor superfamily member 19L precursor
Function of the protein in oral and tooth development
Relt-/- mice generated by CRISPR/Cas9 exhibited incisor and molar enamel malformations. Relt-/- enamel had a rough surface and underwent rapid attrition (Kim et al., 2019).
Dental and Oral Diseases
Amelogenesis imperfecta, type IIIC
(OMIM ID: 611211)
Protein Sequence
>NP_689408.1 tumor necrosis factor receptor superfamily member 19L precursor [Homo sapiens]
MKPSLLCRPLSCFLMLLPWPLATLTSTTLWQCPPGEEPDLDPGQGTLCRPCPPGTFSAAWGSSPCQPHAR
CSLWRRLEAQVGMATRDTLCGDCWPGWFGPWGVPRVPCQPCSWAPLGTHGCDEWGRRARRGVEVAAGASS
GGETRQPGNGTRAGGPEETAAQYAVIAIVPVFCLMGLLGILVCNLLKRKGYHCTAHKEVGPGPGGGGSGI
NPAYRTEDANEDTIGVLVRLITEKKENAAALEELLKEYHSKQLVQTSHRPVSKLPPAPPNVPHICPHRHH
LHTVQGLASLSGPCCSRCSQKKWPEVLLSPEAVAATTPVPSLLPNPTRVPKAGAKAGRQGEITILSVGRF
RVARIPEQRTSSMVSEVKTITEAGPSWGDLPDSPQPGLPPEQQALLGSGGSRTKWLKPPAENKAEENRYV
VRLSESNLVI
Mutations
2-BP DEL, 1169CT; ARG422PRO; IVS3AS, A-G, -2: Kim et al. (2019).
Related Literature
Kim et al., (2019): https://doi.org/10.1111/cge.13487
