Bioinformatics Database
PRKAR1A: Protein kinase cAMP-dependent type I regulatory subunit alpha
Cellular Process
Cap stage of tooth development
Gene Name
PRKAR1A: Protein kinase cAMP-dependent type I regulatory subunit alpha
Gene ID
5573
Gene Sequence
General Description
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. This gene encodes one of the regulatory subunits. This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2.
Alternative titles; symbols
PROTEIN KINASE A, RI-ALPHA SUBUNIT TISSUE-SPECIFIC EXTINGUISHER 1; TSE1
Chromosome
Chromosome 17
Cytogenetic location
17q24.2
Encoded Protein
cAMP-dependent protein kinase type I-alpha regulatory subunit isoform a
Function of the protein in oral and tooth development
Protein kinase A (PKA) is known to play croles in cell proliferation, cell differentiation, cellular metabolism and gene regulation. de Sousa et al., (2014) aimed to study the expression of alpha isoforms of PKA regulatory subunit (Prkar1a and Prkar2a) in mouse and human odontogenesis by in situ hybridization. From the resutls PRKAR1A and PRKAR2A mRNA transcription was confirmed in a human deciduous germ by qRT-PCR. Mouse Prkar1a and human PRKAR2A exhibited a dynamic spatio-temporal expression in tooth development. However, neither human PRKAR1A nor mouse Prkar2a showed their expression in odontogenesis (de Sousa et al., 2014).
Dental and Oral Diseases
Protein Sequence
>NP_001265362.1 cAMP-dependent protein kinase type I-alpha regulatory subunit isoform a [Homo sapiens]
MESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKEEAKQIQNLQK
AGTRTDSREDEISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPKDYKTMAALAKAIEKNVLFSH
LDDNERSDIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQGETDVYVNNEWATSVGEGGSFGELALIYGTP
RAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQ
KIVVQGEPGDEFFIILEGSAAVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKL
DRPRFERVLGPCSDILKRNIQQYNSFVSLSV
Mutations
Related Literature
de Sousa et al., (2014). https://doi.org/10.1016/j.gep.2014.04.002
