Bioinformatics Database
MME: Membrane metalloendopeptidase
3D Protein Structure Viewer
Cellular Process
Cap stage of tooth development
Gene Name
MME: Membrane metalloendopeptidase
Gene ID
4311
Gene Sequence
General Description
The protein encoded by this gene is a type II transmembrane glycoprotein and a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). The encoded protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin.
Alternative titles; symbols
COMMON ACUTE LYMPHOCYTIC LEUKEMIA ANTIGEN (CALLA) CD10 NEPRILYSIN NEUTRAL ENDOPEPTIDASE, MEMBRANE-ASSOCIATED (NEP) ENKEPHALINASE ATRIOPEPTIDASE
Chromosome
Chromosome 3
Cytogenetic location
3q25.2
Encoded Protein
Neprilysin isoform a
Function of the protein in oral and tooth development
Liu et al., (2009) investigated the differential expression of stem cell-related genes in dental pulp cells (DPCs) and periodontal ligament cells (PDLCs) undergoing odontogenic/osteogenic differentiation. Their study results showed that MME was one of the major upregulated genes in both PDLCs and DPCs. The authors suggest that the alternerly experessed genes may interact through the Notch, Wnt, TGF-beta/BMP, and cadherin signaling pathways to play a crucial role in determining the fate of dental derived cell and dental tissue regeneratio ( Liu et al., 2009).
Dental and Oral Diseases
Protein Sequence
>NP_009220.2 neprilysin isoform a [Homo sapiens]
MGKSESQMDITDINTPKPKKKQRWTPLEISLSVLVLLLTIIAVTMIALYATYDDGICKSSDCIKSAARLI
QNMDATTEPCTDFFKYACGGWLKRNVIPETSSRYGNFDILRDELEVVLKDVLQEPKTEDIVAVQKAKALY
RSCINESAIDSRGGEPLLKLLPDIYGWPVATENWEQKYGASWTAEKAIAQLNSKYGKKVLINLFVGTDDK
NSVNHVIHIDQPRLGLPSRDYYECTGIYKEACTAYVDFMISVARLIRQEERLPIDENQLALEMNKVMELE
KEIANATAKPEDRNDPMLLYNKMTLAQIQNNFSLEINGKPFSWLNFTNEIMSTVNISITNEEDVVVYAPE
YLTKLKPILTKYSARDLQNLMSWRFIMDLVSSLSRTYKESRNAFRKALYGTTSETATWRRCANYVNGNME
NAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKRAEEKALAIKERIGYPDDIVSND
NKLNNEYLELNYKEDEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAAVVNAFYSSGRNQIVFPAGIL
QPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKDGDLVDWWTQQSASNFKEQSQCMVYQYGNFS
WDLAGGQHLNGINTLGENIADNGGLGQAYRAYQNYIKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRP
EYAVNSIKTDVHSPGNFRIIGTLQNSAEFSEAFHCRKNSYMNPEKKCRVW
Mutations
Related Literature
Liu et al., (2009). https://doi.org/10.1016/j.joen.2009.07.005
