Bioinformatics Database
MIR185: microRNA 185
Cellular Process
Enamel formation
Gene Name
MIR185: microRNA 185
Gene ID
406961
Gene Sequence
General Description
MicroRNAs (miRNAs), such as MIR185, are short noncoding RNAs that typically basepair with the 3-prime UTRs of target mRNAs and either suppress translation or induce mRNA degradation. The MIR185 stem-loop sequence encodes 2 mature miRNAs, MIR185 (MIR185-5p) and MIR185* (MIR185-3p), from its 5-prime and 3-prime ends, respectively (Liao & Lu, 2011).
Alternative titles; symbols
miRNA185 MIR185-5p
Chromosome
Chromosome 22
Cytogenetic location
22q11.21
Encoded Protein
Function of the protein in oral and tooth development
The miRNA pathway is evident to have significant importance in embryogenesis including tooth development. miRNAs are found to regulate morphogenesis of tooth by fine-tuning the signalling networks. However, their precise role in tooth differentiation and morphogenesis is unclear (Khuu et al., 2016)
Dental and Oral Diseases
Protein Sequence
Mutations
Related Literature
Liao & Lu, (2011): https://doi.org/10.1074/jbc.M111.262030
Khuu et al., (2016): https://doi.org/10.2174/2211536605666160706003256
