Bioinformatics Database
LEF1: Lymphoid enhancer binding factor 1
Cellular Process
Bud stage of tooth development
Gene Name
LEF1: Lymphoid enhancer binding factor 1
Gene ID
51176
Gene Sequence
General Description
This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis.
Alternative titles; symbols
TRANSCRIPTION FACTOR, T CELL-SPECIFIC, 1, ALPHA TCF1-ALPHA
Chromosome
Chromosome 4
Cytogenetic location
4q25
Encoded Protein
Lymphoid enhancer-binding factor 1 isoform 1
Function of the protein in oral and tooth development
Kratochwil et al. (2002) investigated LEF1 function in inductive signaling during tooth development and concluded that FGF4 is a direct target of Lef1 and Wnt signaling. They observed that developmentally arrested tooth rudiments in Lef1 null mice (Van Genderen et al., 1994) failed to express Fgf4, Shh, and Bmp4. Kratochwil et al. (2002) generated mice carrying a mutation to eliminate the interaction of LEF1 with CTNNB1, and concluded that the role of LEF1 in tooth development is dependent on its interaction with CTNNB1 and Wnt signaling. Studies also evident taht LEF-1 is expressed in the dental epithelium at the initiation of tooth development and is required for early tooth development (Sasaki et al. 2005). The expression domains of LEF-1 is shown to define the epithelial component of the dental placode (Chen et al., 2022). Wu et al., (2017) reported the expression of Wnt/β-catenin signaling genes of DM3 ( third deciduous molar in miniature pig ) at cap, early bell and late bell stage. The authors found that Lef1 and Axin2 were expressed in the enamel knot and underlying mesenchyme regions. Homeobox protein MSX-1 interacts with LEF-1 and LEF-1 promotes odontoblast differentiation during tooth-germ development. Msx1-deficient mice are characterized by arrest of tooth-germ development at the bud stage, along with decreased expression of bone morphogenetic protein 2 (Bmp2), bone morphogenetic protein 4 (Bmp4), lymphoid enhancer binding factor 1 (Lef1), and other downstream genes (Feng et al, 2018)
Dental and Oral Diseases
Protein Sequence
>NP_057353.1 lymphoid enhancer-binding factor 1 isoform 1 [Homo sapiens]
MPQLSGGGGGGGGDPELCATDEMIPFKDEGDPQKEKIFAEISHPEEEGDLADIKSSLVNESEIIPASNGH
EVARQAQTSQEPYHDKAREHPDDGKHPDGGLYNKGPSYSSYSGYIMMPNMNNDPYMSNGSLSPPIPRTSN
KVPVVQPSHAVHPLTPLITYSDEHFSPGSHPSHIPSDVNSKQGMSRHPPAPDIPTFYPLSPGGVGQITPP
LGWQGQPVYPITGGFRQPYPSSLSVDTSMSRFSHHMIPGPPGPHTTGIPHPAIVTPQVKQEHPHTDSDLM
HVKPQHEQRKEQEPKRPHIKKPLNAFMLYMKEMRANVVAECTLKESAAINQILGRRWHALSREEQAKYYE
LARKERQLHMQLYPGWSARDNYGKKKKRKREKLQESASGTGPRMTAAYI
Mutations
Related Literature
Kratochwil et al. (2002). https://doi.org/10.1101/gad.1035602
van Genderen et al. (1994). https://doi.org/10.1101/gad.8.22.2691
Feng et al, (2018). https://doi.org/10.1111/eos.12390
Sasaki et al. 2005. LEF1 is a critical epithelial survival factor during tooth morphogenesis. Dev Biol. 278(1):130–143.
Chen et al. (2022). https://doi.org/10.1177/00220345211046590
Wu et al., (2017). https://doi.org/10.7150/ijbs.20905
