Bioinformatics Database
KLK5: Kallikrein related peptidase 5

Cellular Process
Enamel formation
Gene Name
KLK5: kallikrein related peptidase 5
Gene ID
25818
Gene Sequence
General Description
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its expression is up-regulated by estrogens and progestins. The encoded protein is secreted and may be involved in desquamation in the epidermis. Alternative splicing results in multiple transcript variants encoding the same protein.
Alternative titles; symbols
KALLIKREIN 5 STRATUM CORNEUM TRYPTIC ENZYME; SCTE KALLIKREIN-LIKE 2; KLKL2
Chromosome
Chromosome 19
Cytogenetic location
19q13.41
Encoded Protein
Kallikrein-5 preproprotein
Function of the protein in oral and tooth development
Kawasaki et al., (2014) searched multiple databases, retrieved Klk4 and Klk5 from various mammalian genomes, and identified Klk5 in both marsupial and eutherian mammals. Authors performed phylogenetic and mutation rate analyses and hypothesized that "Klk4 arose from Klk5 by gene duplication near the divergence of Afrotheria, Xenarthra and Boreoeutheria, and that functionally-differentiated Klk4 survived only in Boreoeutheria. Afrotherian mammals share the feature of delayed dental eruption relative to boreoeutherian mammals. KLK4 shortens the time required for enamel maturation and could have alleviated negative selection following mutations that resulted in thicker enamel or earlier tooth eruption, without reducing enamel hardness or causing dental attrition." (Kawasaki et al., 2014).
Dental and Oral Diseases
Protein Sequence
>NP_036559.1 kallikrein-5 preproprotein [Homo sapiens]
MATARPPWMWVLCALITALLLGVTEHVLANNDVSCDHPSNTVPSGSNQDLGAGAGEDARSDDSSSRIING
SDCDMHTQPWQAALLLRPNQLYCGAVLVHPQWLLTAAHCRKKVFRVRLGHYSLSPVYESGQQMFQGVKSI
PHPGYSHPGHSNDLMLIKLNRRIRPTKDVRPINVSSHCPSAGTKCLVSGWGTTKSPQVHFPKVLQCLNIS
VLSQKRCEDAYPRQIDDTMFCAGDKAGRDSCQGDSGGPVVCNGSLQGLVSWGDYPCARPNRPGVYTNLCK
FTKWIQETIQANS
Mutations
Related Literature
Kawasaki et al., (2014): https://doi.org/10.1515/hsz-2014-0122