Bioinformatics Database
KCNJ2: Potassium inwardly rectifying channel subfamily J member 2

3D Protein Structure Viewer
Cellular Process
Tooth Eruption
Gene Name
KCNJ2: Potassium inwardly rectifying channel subfamily J member 2
Gene ID
3759
Gene Sequence
General Description
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues.
Alternative titles; symbols
HHIRK1 IRK1 KIR2.1
Chromosome
Chromosome 17
Cytogenetic location
17q24.3
Encoded Protein
Inward rectifier potassium channel 2
Function of the protein in oral and tooth development
Fatemifar et al.,(2013) conducted genome-wide association study and reported association of six loci with primary tooth eruption including KCNJ2/KCNJ16, IGF2BP1, and EDA.
Dental and Oral Diseases
Protein Sequence
>NP_000882.1 inward rectifier potassium channel 2 [Homo sapiens]
MGSVRTNRYSIVSSEEDGMKLATMAVANGFGNGKSKVHTRQQCRSRFVKKDGHCNVQFINVGEKGQRYLA
DIFTTCVDIRWRWMLVIFCLAFVLSWLFFGCVFWLIALLHGDLDASKEGKACVSEVNSFTAAFLFSIETQ
TTIGYGFRCVTDECPIAVFMVVFQSIVGCIIDAFIIGAVMAKMAKPKKRNETLVFSHNAVIAMRDGKLCL
MWRVGNLRKSHLVEAHVRAQLLKSRITSEGEYIPLDQIDINVGFDSGIDRIFLVSPITIVHEIDEDSPLY
DLSKQDIDNADFEIVVILEGMVEATAMTTQCRSSYLANEILWGHRYEPVLFEEKHYYKVDYSRFHKTYEV
PNTPLCSARDLAEKKYILSNANSFCYENEVALTSKEEDDSENGVPESTSTDTPPDIDLHNQASVPLEPRP
LRRESEI
Mutations
Related Literature
Fatemifar et al.,(2013). https://doi.org/10.1093/hmg/ddt231