Bioinformatics Database
KCNJ16: Potassium inwardly rectifying channel subfamily J member 16
3D Protein Structure Viewer
Cellular Process
Tooth Eruption
Gene Name
KCNJ16: Potassium inwardly rectifying channel subfamily J member 16
Gene ID
3773
Gene Sequence
General Description
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which tends to allow potassium to flow into rather than out of a cell, can form heterodimers with two other inward-rectifier type potassium channels. It may function in fluid and pH balance regulation.
Alternative titles; symbols
KIR5.1
Chromosome
Chromosome 17
Cytogenetic location
17q24.3
Encoded Protein
Inward rectifier potassium channel 16 isoform b
Function of the protein in oral and tooth development
Fatemifar et al.,(2013) conducted genome-wide association study and reported association of six loci with primary tooth eruption including KCNJ2/KCNJ16, IGF2BP1, and EDA.
Dental and Oral Diseases
Protein Sequence
>NP_733937.3 inward rectifier potassium channel 16 isoform b [Homo sapiens]
MSYYGSSYHIINADAKYPGYPPEHIIAEKRRARRRLLHKDGSCNVYFKHIFGEWGSYVVDIFTTLVDTKW
RHMFVIFSLSYILSWLIFGSVFWLIAFHHGDLLNDPDITPCVDNVHSFTGAFLFSLETQTTIGYGYRCVT
EECSVAVLMVILQSILSCIINTFIIGAALAKMATARKRAQTIRFSYFALIGMRDGKLCLMWRIGDFRPNH
VVEGTVRAQLLRYTEDSEGRMTMAFKDLKLVNDQIILVTPVTIVHEIDHESPLYALDRKAVAKDNFEILV
TFIYTGDSTGTSHQSRSSYVPREILWGHRFNDVLEVKRKYYKVNCLQFEGSVEVYAPFCSAKQLDWKDQQ
LHIEKAPPVRESCTSDTKARRRSFSAVAIVSSCENPEETTTSATHEYRETPYQKALLTLNRISVESQM
Mutations
Related Literature
Fatemifar et al.,(2013). https://doi.org/10.1093/hmg/ddt231
