Bioinformatics Database
IGF2BP1: Insulin like growth factor 2 mRNA binding protein 1
3D Protein Structure Viewer
Cellular Process
Tooth Eruption
Gene Name
IGF2BP1: Insulin like growth factor 2 mRNA binding protein 1
Gene ID
10642
Gene Sequence
General Description
This gene encodes a member of the insulin-like growth factor 2 mRNA-binding protein family. The protein encoded by this gene contains four K homology domains and two RNA recognition motifs. It functions by binding to the mRNAs of certain genes, including insulin-like growth factor 2, beta-actin and beta-transducin repeat-containing protein, and regulating their translation.
Alternative titles; symbols
IGF2 mRNA-BINDING PROTEIN 1; IMP1 CODING REGION DETERMINANT-BINDING PROTEIN, MOUSE, HOMOLOG OF; CRDBP ZIPCODE-BINDING PROTEIN 1; ZBP1
Chromosome
Chromosome 17
Cytogenetic location
17q21.32
Encoded Protein
Insulin-like growth factor 2 mRNA-binding protein 1 isoform 1
Function of the protein in oral and tooth development
Pillas et al., (2010) performed a genome-wide association study of time to first tooth eruption. The results identified 5 loci and several genes with links to tooth and other organ development including EDA and IGF2BP1.
Dental and Oral Diseases
Protein Sequence
>NP_006537.3 insulin-like growth factor 2 mRNA-binding protein 1 isoform 1 [Homo sapiens]
MNKLYIGNLNESVTPADLEKVFAEHKISYSGQFLVKSGYAFVDCPDEHWAMKAIETFSGKVELQGKRLEI
EHSVPKKQRSRKIQIRNIPPQLRWEVLDSLLAQYGTVENCEQVNTESETAVVNVTYSNREQTRQAIMKLN
GHQLENHALKVSYIPDEQIAQGPENGRRGGFGSRGQPRQGSPVAAGAPAKQQQVDIPLRLLVPTQYVGAI
IGKEGATIRNITKQTQSKIDVHRKENAGAAEKAISVHSTPEGCSSACKMILEIMHKEAKDTKTADEVPLK
ILAHNNFVGRLIGKEGRNLKKVEQDTETKITISSLQDLTLYNPERTITVKGAIENCCRAEQEIMKKVREA
YENDVAAMSLQSHLIPGLNLAAVGLFPASSSAVPPPPSSVTGAAPYSSFMQAPEQEMVQVFIPAQAVGAI
IGKKGQHIKQLSRFASASIKIAPPETPDSKVRMVIITGPPEAQFKAQGRIYGKLKEENFFGPKEEVKLET
HIRVPASAAGRVIGKGGKTVNELQNLTAAEVVVPRDQTPDENDQVIVKIIGHFYASQMAQRKIRDILAQV
KQQHQKGQSNQAQARRK
Mutations
Related Literature
Pillas et al., (2010). https://doi.org/10.1371/journal.pgen.1000856
