Bioinformatics Database
HIF1A: Hypoxia inducible factor 1 subunit alpha
3D Protein Structure Viewer
Cellular Process
Cap stage of tooth development
Gene Name
HIF1A: Hypoxia inducible factor 1 subunit alpha
Gene ID
3091
Gene Sequence
General Description
This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease.
Alternative titles; symbols
HIF1-ALPHA MEMBER OF PAS SUPERFAMILY 1; MOP1
Chromosome
Chromosome 14
Cytogenetic location
14q23.2
Encoded Protein
Hypoxia-inducible factor 1-alpha isoform 1
Function of the protein in oral and tooth development
Kimura et al. (2022) designed a study to understand the role of hypoxia inducible factor (HIF) in ameloblast differentiation during tooth germ development using HIF inhibitors. The results showed that the HIF-2α inhibitor significantly decreased the size of tooth germs in organ culture, while the HIF-1α inhibitor did not apparently affect the size of tooth germs.
Orikasa et al., (2022), on the other hand reproted that hypoxia-inducible factor 1α can induce odontoblast differentiation of human dental pulp stem cells via Wnt/β-catenin transcriptional cofactor BCL9.
Dental and Oral Diseases
Protein Sequence
>NP_001521.1 hypoxia-inducible factor 1-alpha isoform 1 [Homo sapiens]
MEGAGGANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVR
KLLDAGDLDIEDDMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCD
HEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRGRTMNIKSATWKVLHCTGHIHVYDTNSNQPQC
GYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYH
ALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDL
IFSLQQTECVLKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTET
DDQQLEEVPLYNDVMLPSPNEKLQNINLAMSPLPTAETPKPLRSSADPALNQEVALKLEPNPESLELSFT
MPQIQDQTPSPSDGSTRQSSPEPNSPSEYCFYVDSDMVNEFKLELVEKLFAEDTEAKNPFSTQDTDLDLE
MLAPYIPMDDDFQLRSFDQLSPLESSSASPESASPQSTVTVFQQTQIQEPTANATTTTATTDELKTVTKD
RMEDIKILIASPSPTHIHKETTSATSSPYRDTQSRTASPNRAGKGVIEQTEKSHPRSPNVLSVALSQRTT
VPEEELNPKILALQNAQRKRKMEHDGSLFQAVGIGTLLQQPDDHAATTSLSWKRVKGCKSSEQNGMEQKT
IILIPSDLACRLLGQSMDESGLPQLTSYDCEVNAPIQGSRNLLQGEELLRALDQVN
Mutations
Related Literature
Kimura et al. (2022). https://doi.org/10.1177/00220345221111971
Orikasa et al., (2022). https://doi.org/10.1038/s41598-021-04453-8
