Bioinformatics Database
GPR68: G protein-coupled receptor 68
3D Protein Structure Viewer
Cellular Process
Enamel formation
Gene Name
GPR68: G protein-coupled receptor 68
Gene ID
8111
Gene Sequence
General Description
The protein encoded by this gene is a G protein-coupled receptor for sphingosylphosphorylcholine. The encoded protein is a proton-sensing receptor, inactive at pH 7.8 but active at pH 6.8.
Alternative titles; symbols
OVARIAN CANCER G PROTEIN-COUPLED RECEPTOR 1; OGR1
Chromosome
Chromosome 14
Cytogenetic location
14q32.11
Encoded Protein
Ovarian cancer G-protein coupled receptor 1
Function of the protein in oral and tooth development
Using immunohistochemistry, Parry et al. (2016) found that GPR68 is expressed in the enamel organ, including in ameloblast cells, during all stages of amelogenesis in rat. The authors observed staining of the apical surface of ameloblasts with anti-GPR68, indicating a possible role for GPR68 as a pH monitor of the developing enamel matrix (Parry et al., 2016).
Dental and Oral Diseases
Amelogenesis imperfecta, hypomaturation type, IIA6
(OMIM ID: 601404)
Protein Sequence
>NP_001171147.1 ovarian cancer G-protein coupled receptor 1 [Homo sapiens]
MGNITADNSSMSCTIDHTIHQTLAPVVYVTVLVVGFPANCLSLYFGYLQIKARNELGVYLCNLTVADLFY
ICSLPFWLQYVLQHDNWSHGDLSCQVCGILLYENIYISVGFLCCISVDRYLAVAHPFRFHQFRTLKAAVG
VSVVIWAKELLTSIYFLMHEEVIEDENQHRVCFEHYPIQAWQRAINYYRFLVGFLFPICLLLASYQGILR
AVRRSHGTQKSRKDQIQRLVLSTVVIFLACFLPYHVLLLVRSVWEASCDFAKGVFNAYHFSLLLTSFNCV
ADPVLYCFVSETTHRDLARLRGACLAFLTCSRTGRAREAYPLGAPEASGKSGAQGEEPELLTKLHPAFQT
PNSPGSGGFPTGRLA
Mutations
450-BP DEL, NT386;
2-BP DEL, NT667;
LEU74PRO
(Parry et al., 2016)
Related Literature
Parry et al., (2016): https://doi.org/10.1016/j.ajhg.2016.08.020
