Bioinformatics Database
ESRRB: Estrogen-related receptor beta
3D Protein Structure Viewer
Cellular Process
Enamel formation
Gene Name
ESRRB: Estrogen related receptor beta
Gene ID
2103
Gene Sequence
General Description
This gene encodes a protein with similarity to the estrogen receptor. Its function is unknown; however, a similar protein in mouse plays an essential role in placental development.
Alternative titles; symbols
ESTROGEN RECEPTOR-LIKE 2; ESRL2 ESTROGEN-RELATED RECEPTOR 2; ERR2
Chromosome
Chromosome 14
Cytogenetic location
14q24.3
Encoded Protein
Steroid hormone receptor ERR2 isoform 2
Function of the protein in oral and tooth development
Weber et al., (2014) found that families with recessive ESRRB mutations and hearing impairment showed more extensive dental destruction by caries. ESRRB experession in whole saliva also showed differences depending on sex and dental caries experience (Weber et al., 2014).
Dental and Oral Diseases
Protein Sequence
>NP_001366109.1 steroid hormone receptor ERR2 isoform 2 [Homo sapiens]
MDVSELCIPDPLGYHNQLLNRMSSDDRHLGSSCGSFIKTEPSSPSSGIDALSHHSPSGSSDASGGFGLAL
GTHANGLDSPPMFAGAGLGGTPCRKSYEDCASGIMEDSAIKCEYMLNAIPKRLCLVCGDIASGYHYGVAS
CEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRL
DSESSPYLSLQISPPAKKPLTKIVSYLLVAEPDKLYAMPPPGMPEGDIKALTTLCDLADRELVVIIGWAK
HIPGFSSLSLGDQMSLLQSAWMEILILGIVYRSLPYDDKLVYAEDYIMDEEHSRLAGLLELYRAILQLVR
RYKKLKVEKEEFVTLKALALANSDSMYIEDLEAVQKLQDLLHEALQDYELSQRHEEPWRTGKLLLTLPLL
RQTAAKAVQHFYSVKLQGKVPMHKLFLEMLEAKV
Mutations
Related Literature
Weber et al., (2014): https://doi.org/10.1186/1471-2350-15-81
