Bioinformatics Database
EGFR: Epidermal growth factor receptor
Cellular Process
Cap stage of tooth development
Gene Name
EGFR: Epidermal growth factor receptor
Gene ID
1956
Gene Sequence
General Description
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor, thus inducing receptor dimerization and tyrosine autophosphorylation leading to cell proliferation.
Alternative titles; symbols
V-ERB-B AVIAN ERYTHROBLASTIC LEUKEMIA VIRAL ONCOGENE HOMOLOG ONCOGENE ERBB ERBB1 HER1 SPECIES ANTIGEN 7; SA7
Chromosome
Chromosome 7
Cytogenetic location
7p11.2
Encoded Protein
Epidermal growth factor receptor isoform A precursor
Function of the protein in oral and tooth development
Shroff et al. (1996) studied the expression of epidermal growth factor (EGF) and EGF-receptor genes in the coronal aspect of the dental follicle. First molars from 2-, 5-, 9- and 11-day-old CD-1 mouse neonates were incubated in 1% trypsin for 1.5 h at 4 degrees C. Follicles were carefully separated from the coronal aspect of the molar and processed for RNA extraction. Reverse transcriptase-polymerase chain reaction was performed on each mRNA sample. EGF expression was detected at day 2, 5 and 9 in the coronal aspect of the follicle whereas EGF-receptor expression was found at day 9 only. These findings indicates that cells of the dental follicle are the target of EGF at a specific stage of their development and therefore may have a very important role during eruption (Shroff et al., 1996) .
Dental and Oral Diseases
Protein Sequence
>NP_005219.2 epidermal growth factor receptor isoform a precursor [Homo sapiens]
MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYV
QRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNL
QEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKL
TKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVN
PEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLS
INATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAF
ENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKI
ISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHP
ECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTG
PGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPN
QALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVD
NPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAA
RNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTF
GSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLV
IQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACI
DRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPS
RDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGS
TAENAEYLRVAPQSSEFIGA
Mutations
Related Literature
Shroff et al. (1996). https://doi.org/10.1016/0003-9969(96)00147-1
