Bioinformatics Database
DLEU7: Deleted in lymphocytic leukemia 7

3D Protein Structure Viewer
Cellular Process
Tooth Eruption
Gene Name
DLEU7: Deleted in lymphocytic leukemia 7
Gene ID
220107
Gene Sequence
General Description
DLEU7 is a widely expressed gene located adjacent to the consensus 13q14 deletion region in B-cell chronic lymphocytic leukemia (BCLL). Using bisulfite sequencing analysis, Hammarsund et al. (2004) found that the DLEU7 promoter was hypermethylated in BCLL patient cells, consistent with the lack of DLEU7 expression in these patients.
Alternative titles; symbols
DLEU7
Chromosome
Chromosome 13
Cytogenetic location
13q14.3
Encoded Protein
Leukemia-associated protein 7 isoform 2
Function of the protein in oral and tooth development
Fatemifar et al.,(2013) conducted genome-wide association study and report genetic variants at 15 loci associated with primary tooth eruption at genome-wide significant levels, including 8 novel variants within or near the following genes: BMP4, CACNB2, CDON, CALU/OPN1SW, AJUBA/C14orf93, DLEU7, TEX14/RAD51C and ADK.
Dental and Oral Diseases
Protein Sequence
>NP_945340.2 leukemia-associated protein 7 isoform 2 [Homo sapiens]
MASPAPLVASISHQMVALQTLQLLQQEWGWGDGPVAPGNPRDPDHVSTAPARRSGPPRARPGPGREERGG
GVGTRSRRTAARANSPEEEVVRGAEGGAELLPFPRDRGPCTLAQMAMRSALARVVDSTSELVSVEQTLLG
PLQQERSFPIHLKLQLLANE
Mutations
Related Literature
Fatemifar et al.,(2013). https://doi.org/10.1093/hmg/ddt231
Hammarsund et al., (2004). https://doi.org/10.1016/s0014-5793(03)01371-1