Bioinformatics Database
CTNNBIP1: Catenin beta interacting protein 1
Cellular Process
Bud stage of tooth development
Gene Name
CTNNBIP1: Catenin beta interacting protein 1
Gene ID
56998
Gene Sequence
General Description
The protein encoded by this gene binds CTNNB1 and prevents interaction between CTNNB1 and TCF family members. The encoded protein is a negative regulator of the Wnt signaling pathway.
Alternative titles; symbols
INHIBITOR OF BETA-CATENIN AND TCF4; ICAT
Chromosome
Chromosome 1
Cytogenetic location
1p36.22
Encoded Protein
Beta-catenin-interacting protein 1
Function of the protein in oral and tooth development
Wang et al. (2014) studied the expression patterns of WNT/β-CATENIN signaling components in human tooth germ at the bud, cap and bell stages by in situ hybridization. They identified that the transcription factors TCF4 showed no expression during the bud and cap stages (8 and 12 week of development), but positive TCF4 staining predominantly localized in internal enamel epithelium during the 15 week bell stage. Using in-situ hybridization, Wu et al., (2017) found that Tcf4 was mainly expressed at the mesenchyme region at E40. At E50 and E60, the expression of Tcf4 in dental papilla was more homogeneous than those of other genes and the signal in IEE became stronger. In addition, the expression of Tcf4 could be clearly observed in pre-odontoblasts and odontoblasts at E60.
Dental and Oral Diseases
Protein Sequence
NP_064633.1 beta-catenin-interacting protein 1 [Homo sapiens]
MNREGAPGKSPEEMYIQQKVRVLLMLRKMGSNLTASEEEFLRTYAGVVNSQLSQLPPHSIDQGAEDVVMA FSRSETEDRRQ
Mutations
Related Literature
Wu et al, (2017). https://doi.org/10.7150/ijbs.20905
Wang et al., (2014). https://doi.org/10.1007/s10735-014-9572-5
