Bioinformatics Database
CSF3R: Colony Stimulating Factor 3 Receptor

Cellular Process
Enamel formation
Gene Name
CSF3R: Colony Stimulating Factor 3 Receptor
Gene ID
1441
Gene Sequence
General Description
The CSF3R gene encodes the receptor for granulocyte colony-stimulating factor, a 20- to 25-kD glycoprotein produced by macrophages stimulated with endotoxin, that plays an important role in granulopoiesis during the inflammatory process.
Alternative titles; symbols
Granulocyte Colony Stimulating Factor Receptor; GCSFR
Chromosome
Chromosome 1
Cytogenetic location
1p34.3
Encoded Protein
Granulocyte Colony-Stimulating Factor Receptor isoform A precursor.
Function of the protein in oral and tooth development
Murakami et al. (2013) found that granulocyte-colony stimulating factor induced mobilization of dental pulp stem cell.
Otsuji et al. (1999) used whole-head, freeze-dried sections at the level of the mandibular first and second molar from newborn and 5-day-old rats. These sections were not demineralized or fixed, reducing the possibility of false-negative results. Antibodies to the IFNgamma r and the granulocyte colony-stimulating factor (G-CSF) receptor were localized using a modification of the avidin-biotin complex method. The G-CSF receptor was observed in the molars of newborn rats in the preameloblasts, the proximal and distal ends of the presecretory ameloblasts, outer enamel epithelium, and in bone. In 5-day-old rats, G-CSF receptor was localized in the preameloblasts, the proximal ends of presecretory and secretory ameloblasts, the stellate reticulum, the outer enamel epithelium, and in bone.
Dental and Oral Diseases
Protein Sequence
>NP_000751.1 granulocyte colony-stimulating factor receptor isoform a precursor [Homo sapiens]
MARLGNCSLTWAALIILLLPGSLEECGHISVSAPIVHLGDPITASCIIKQNCSHLDPEPQILWRLGAELQ
PGGRQQRLSDGTQESIITLPHLNHTQAFLSCCLNWGNSLQILDQVELRAGYPPAIPHNLSCLMNLTTSSL
ICQWEPGPETHLPTSFTLKSFKSRGNCQTQGDSILDCVPKDGQSHCCIPRKHLLLYQNMGIWVQAENALG
TSMSPQLCLDPMDVVKLEPPMLRTMDPSPEAAPPQAGCLQLCWEPWQPGLHINQKCELRHKPQRGEASWA
LVGPLPLEALQYELCGLLPATAYTLQIRCIRWPLPGHWSDWSPSLELRTTERAPTVRLDTWWRQRQLDPR
TVQLFWKPVPLEEDSGRIQGYVVSWRPSGQAGAILPLCNTTELSCTFHLPSEAQEVALVAYNSAGTSRPT
PVVFSESRGPALTRLHAMARDPHSLWVGWEPPNPWPQGYVIEWGLGPPSASNSNKTWRMEQNGRATGFLL
KENIRPFQLYEIIVTPLYQDTMGPSQHVYAYSQEMAPSHAPELHLKHIGKTWAQLEWVPEPPELGKSPLT
HYTIFWTNAQNQSFSAILNASSRGFVLHGLEPASLYHIHLMAASQAGATNSTVLTLMTLTPEGSELHIIL
GLFGLLLLLTCLCGTAWLCCSPNRKNPLWPSVPDPAHSSLGSWVPTIMEEDAFQLPGLGTPPITKLTVLE
EDEKKPVPWESHNSSETCGLPTLVQTYVLQGDPRAVSTQPQSQSGTSDQVLYGQLLGSPTSPGPGHYLRC
DSTQPLLAGLTPSPKSYENLWFQASPLGTLVTPAPSQEDDCVFGPLLNFPLLQGIRVHGMEALGSF
Mutations
Related Literature
Murakami et al., (2013): https://doi.org/10.1016/j.biomaterials.2013.08.011
Otsuji et al., (1999).
https://doi.org/10.1016/s0003-9969(98)00092-2