Bioinformatics Database

CKAP4: Cytoskeleton associated protein 4 

CKAP4: Cytoskeleton associated protein 4
3D Protein Structure Viewer​
Cellular Process
Enamel formation
Gene Name
CKAP4: Cytoskeleton associated protein 4
Gene ID
10970
General Description
CKAP4 encodes a stable and abundant transmembrane protein predominantly localized to the rough endoplasmic reticulum (RER) where it acts as a spacer that defines the width of ER sheets.
Alternative titles; symbols
CYTOSKELETON-LINKING MEMBRANE PROTEIN 63; CLIMP63 ERGIC63
Chromosome
Chromosome 12
Cytogenetic location
12q23.3
Encoded Protein

Cytoskeleton-associated protein 4

https://www.ncbi.nlm.nih.gov/protein/NP_006816.2/

Function of the protein in oral and tooth development

Studies show that the development of teeth involves a complex sequence of molecular events in which p63 is involved. Mice lacking p63 do not have teeth and humans with mutations in p63 suffer developmental syndromes that affect tooth morphology and number (Rufini et al., 2011)

Dental and Oral Diseases
Protein Sequence
>NP_006816.2 cytoskeleton-associated protein 4 [Homo sapiens]
MPSAKQRGSKGGHGAASPSEKGAHPSGGADDVAKKPPPAPQQPPPPPAPHPQQHPQQHPQNQAHGKGGHR
GGGGGGGKSSSSSSASAAAAAAAASSSASCSRRLGRALNFLFYLALVAAAAFSGWCVHHVLEEVQQVRRS
HQDFSRQREELGQGLQGVEQKVQSLQATFGTFESILRSSQHKQDLTEKAVKQGESEVSRISEVLQKLQNE
ILKDLSDGIHVVKDARERDFTSLENTVEERLTELTKSINDNIAIFTEVQKRSQKEINDMKAKVASLEESE
GNKQDLKALKEAVKEIQTSAKSREWDMEALRSTLQTMESDIYTEVRELVSLKQEQQAFKEAADTERLALQ
ALTEKLLRSEESVSRLPEEIRRLEEELRQLKSDSHGPKEDGGFRHSEAFEALQQKSQGLDSRLQHVEDGV
LSMQVASARQTESLESLLSKSQEHEQRLAALQGRLEGLGSSEADQDGLASTVRSLGETQLVLYGDVEELK
RSVGELPSTVESLQKVQEQVHTLLSQDQAQAARLPPQDFLDRLSSLDNLKASVSQVEADLKMLRTAVDSL
VAYSVKIETNENNLESAKGLLDDLRNDLDRLFVKVEKIHEKV
Mutations
Related Literature