Bioinformatics Database
CCN3: Cellular communication network factor 3
3D Protein Structure Viewer
Cellular Process
Dentin formation
Gene Name
CCN3: Cellular communication network factor 3
Gene ID
4856
Gene Sequence
General Description
The protein encoded by this gene is a small secreted cysteine-rich protein and a member of the CCN family of regulatory proteins. CNN family proteins associate with the extracellular matrix and play an important role in cardiovascular and skeletal development, fibrosis and cancer development.
Alternative titles; symbols
NEPHROBLASTOMA OVEREXPRESSED GENE; NOV ONCOGENE NOV
Chromosome
Chromosome 8
Cytogenetic location
8q24.12
Encoded Protein
CCN family member 3 precursor
Function of the protein in oral and tooth development
CCN3 is known to inhibit osteoblast differentiation in vitro. Research showed that bone regeneration in Ccn3 knock-out mice was increased compared with that in wild-type mice (Matsushita et al., 2013).
Dental and Oral Diseases
Protein Sequence
>NP_002505.1 CCN family member 3 precursor [Homo sapiens]
MQSVQSTSFCLRKQCLCLTFLLLHLLGQVAATQRCPPQCPGRCPATPPTCAPGVRAVLDGCSCCLVCARQ
RGESCSDLEPCDESSGLYCDRSADPSNQTGICTAVEGDNCVFDGVIYRSGEKFQPSCKFQCTCRDGQIGC
VPRCQLDVLLPEPNCPAPRKVEVPGECCEKWICGPDEEDSLGGLTLAAYRPEATLGVEVSDSSVNCIEQT
TEWTACSKSCGMGFSTRVTNRNRQCEMLKQTRLCMVRPCEQEPEQPTDKKGKKCLRTKKSLKAIHLQFKN
CTSLHTYKPRFCGVCSDGRCCTPHNTKTIQAEFQCSPGQIVKKPVMVIGTCTCHTNCPKNNEAFLQELEL
KTTRGKM
Mutations
Related Literature
Matsushita et al., (2013): https://doi.org/10.1074/jbc.M113.454652
