Bioinformatics Database
CCN2: Cellular communication network factor 2
3D Protein Structure Viewer
Cellular Process
Dentin formation
Gene Name
CCN2: Cellular communication network factor 2
Gene ID
1490
Gene Sequence
General Description
The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis.
Alternative titles; symbols
CONNECTIVE TISSUE GROWTH FACTOR; CTGF INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN 8; IGFBP8
Chromosome
Chromosome 6
Cytogenetic location
6q23.2
Encoded Protein
CCN family member 2 precursor
Function of the protein in oral and tooth development
Connective tissue growth factor/CCN family 2 (CTGF/CCN2) has been considered to participate in tooth development. Studies by Muromachi et al., (2012) suggest that CTGF/CCN2 is likely involved in reparative dentinogenesis through formation of hard tissue in human carious teeth.
Dental and Oral Diseases
Protein Sequence
>NP_001892.2 CCN family member 2 precursor [Homo sapiens]
MTAASMGPVRVAFVVLLALCSRPAVGQNCSGPCRCPDEPAPRCPAGVSLVLDGCGCCRVCAKQLGELCTE
RDPCDPHKGLFCHFGSPANRKIGVCTAKDGAPCIFGGTVYRSGESFQSSCKYQCTCLDGAVGCMPLCSMD
VRLPSPDCPFPRRVKLPGKCCEEWVCDEPKDQTVVGPALAAYRLEDTFGPDPTMIRANCLVQTTEWSACS
KTCGMGISTRVTNDNASCRLEKQSRLCMVRPCEADLEENIKKGKKCIRTPKISKPIKFELSGCTSMKTYR
AKFCGVCTDGRCCTPHRTTTLPVEFKCPDGEVMKKNMMFIKTCACHYNCPGDNDIFESLYYRKMYGDMA
Mutations
Related Literature
Muromachi et al., (2012): https://doi.org/10.2334/josnusd.54.47
