Bioinformatics Database
CALCA: Calcitonin related polypeptide alpha

3D Protein Structure Viewer
Cellular Process
Cap stage of tooth development
Gene Name
CALCA: Calcitonin related polypeptide alpha
Gene ID
796
Gene Sequence
General Description
This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator and as an antimicrobial peptide while katacalcin is a calcium-lowering peptide.
Alternative titles; symbols
CALCITONIN; CALC1; CT
Chromosome
Chromosome 11
Cytogenetic location
11p15.2
Encoded Protein
Calcitonin isoform CT preproprotein
Function of the protein in oral and tooth development
As described by Maeda et al., (2019), although calcitonin gene-related peptide-α (CGRPα) is a neurotransmitter that is related to bone formation during development, its expression is not well established to affect the tooth development.
Dental and Oral Diseases
Protein Sequence
>NP_001732.1 calcitonin isoform CT preproprotein [Homo sapiens]
MGFQKFSPFLALSILVLLQAGSLHAAPFRSALESSPADPATLSEDEARLLLAALVQDYVQMKASELEQEQ
EREGSSLDSPRSKRCGNLSTCMLGTYTQDFNKFHTFPQTAIGVGAPGKKRDMSSDLERDHRPHVSMPQNA
N
Mutations
Related Literature
Maeda et al., (2019). https://doi.org/10.1016/j.aanat.2018.09.001