Bioinformatics Database
BSG: basigin (Ok blood group)
3D Protein Structure Viewer
Cellular Process
Cap stage of tooth development
Gene Name
BSG: basigin (Ok blood group)
Gene ID
682
Gene Sequence
General Description
The protein encoded by this gene, basigin, is a plasma membrane protein that is important in spermatogenesis, embryo implantation, neural network formation, and tumor progression. Basigin is also a member of the immunoglobulin superfamily, ubiquitously expressed in various tissues.
Alternative titles; symbols
TCSF EXTRACELLULAR MATRIX METALLOPROTEINASE INDUCER; EMMPRIN M6 LEUKOCYTE ACTIVATION ANTIGEN; M6 CD147 ANTIGEN; CD147
Chromosome
Chromosome 19
Cytogenetic location
19p13.3
Encoded Protein
Basigin isoform 1 precursor
Function of the protein in oral and tooth development
Using immunohistochemistry Xie et al., (2015) reported the expression of extracellular matrix metalloproteinase inducer (EMMPRIN) in ameloblasts and odontoblasts during the middle and late stages of tooth germ development. The results indicates that EMMPRIN may play a critical role in the processing and maturation of the dental matrix (Xie et al., 2015) .
Dental and Oral Diseases
Protein Sequence
>NP_001719.2 basigin isoform 1 precursor [Homo sapiens]
MAAALFVLLGFALLGTHGASGAAGFVQAPLSQQRWVGGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQL
WDGARLDRVHIHATYHQHAASTISIDTLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPG
TVFTTVEDLGSKILLTCSLNDSATEVTGHRWLKGGVVLKEDALPGQKTEFKVDSDDQWGEYSCVFLPEPM
GTANIQLHGPPRVKAVKSSEHINEGETAMLVCKSESVPPVTDWAWYKITDSEDKALMNGSESRFFVSSSQ
GRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITLRVRSHLAALWPFLGIVAEVLVLVTIIFIYEKRRK
PEDVLDDDDAGSAPLKSSGQHQNDKGKNVRQRNSS
Mutations
Related Literature
Xie et al., (2015). https://doi.org/10.1007/s10735-014-9603-2
