Bioinformatics Database
BCL2: BCL2 apoptosis regulator
Cellular Process
Cap stage of tooth development
Gene Name
BCL2: BCL2 apoptosis regulator
Gene ID
596
Gene Sequence
General Description
This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes.
Alternative titles; symbols
ONCOGENE B-CELL LEUKEMIA 2
Chromosome
Chromosome 18
Cytogenetic location
18q21.33
Encoded Protein
Apoptosis regulator Bcl-2 isoform alpha
Function of the protein in oral and tooth development
It is well-established that apoptosis plays a fundamental role in appropriate tissue development and function. Saghiri et al., (2017) studied to investigate the physiological role Bcl-2 in tooth and salivary gland development. In the study, 24 mice were divided into three groups of eight (n=8): group A (Bcl-2 +/+), group B (Bcl-2 +/-), and group C (Bcl-2 -/-) and subjected to micro-CT analyses. The mineral content of first molars was also analyzed. Samples from Bcl-2 -/- mice showed significantly smaller micro-CT values, lower and poor crystallinity of hydroxyapatite (HA), and lowest surface micro hardness. This findings indicated that Bcl-2 expression has a significant impact on the mineralogical content of enamel crystals of tooth structure (Saghiri et al., 2017).
Dental and Oral Diseases
Protein Sequence
>NP_000624.2 apoptosis regulator Bcl-2 isoform alpha [Homo sapiens]
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQP
GHTPHPAASRDPVARTS PLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFS
RRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRD GVNWGRIVAFFEFGGV
MCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRP
LF DFSWLSLKTLLSLALVGACITLGAYLGHK
Mutations
Related Literature
Saghiri et al., (2017). https://doi.org/10.1016/j.yexcr.2017.06.004
