Bioinformatics Database
AMELY: Amelogenin Y-linked
3D Protein Structure Viewer
Cellular Process
Enamel formation
Gene Name
AMELY: Amelogenin Y-linked
Gene ID
266
Gene Sequence
General Description
This gene encodes a member of the amelogenin family of extracellular matrix proteins. Amelogenins are involved in biomineralization during tooth enamel development.
Alternative titles; symbols
AMGY AMELOGENIN-LIKE; AMGL
Chromosome
Chromosome Y
Cytogenetic location
Yp11.2
Encoded Protein
Amelogenin, Y isoform isoform 1 precursor
Function of the protein in oral and tooth development
In humans there are two, non-allelic amelogenin genes: AMELX (Xp22.3) and AMELY (Yp11.2). About 90% of amelogenin expression happens from AMELX. The amelogenin gene on the Y chromosome, AMELY, makes very little amelogenin (Hu et al., 2012). From studies of male developing tooth buds, Salido et al. (1992) presented evidence that both the AMGX gene and the AMGY gene are transcriptionally active.
Dental and Oral Diseases
Protein Sequence
>NP_001134.1 amelogenin, Y isoform isoform 1 precursor [Homo sapiens]
MGTWILFACLVGAAFAMPLPPHPGHPGYINFSYEVLTPLKWYQSMIRPPYSSYGYEPMGGWLHHQIIPVV
SQQHPLTHTLQSHHHIPVVPAQQPRVRQQALMPVPGQQSMTPTQHHQPNLPLPAQQPFQPQPVQPQPHQP
MQPQPPVQPMQPLLPQPPLPPMFPLRPLPPILPDLHLEAWPATDKTKQEEVD
Mutations
Related Literature
Hu et al., (2012): https://doi.org/10.1371/journal.pone.0052052
Salido, E. C., Yen, P. H., Koprivnikar, K., Yu, L. C., & Shapiro, L. J. (1992). The human enamel protein gene amelogenin is expressed from both the X and the Y chromosomes. American journal of human genetics, 50(2), 303–316.
