Bioinformatics Database
AJUBA: Ajuba LIM protein
3D Protein Structure Viewer
Cellular Process
Tooth Eruption
Gene Name
AJUBA: Ajuba LIM protein
Gene ID
84962
Gene Sequence
General Description
Enables alpha-catenin binding activity and transcription corepressor activity. Involved in several processes, including negative regulation of hippo signaling; positive regulation of gene silencing by miRNA; and regulation of cellular response to hypoxia. Acts upstream of or within gene silencing by miRNA and positive regulation of protein-containing complex assembly.
Alternative titles; symbols
AJUBA, MOUSE, HOMOLOG OF; JUB
Chromosome
Chromosome 14
Cytogenetic location
14q11.2
Encoded Protein
LIM domain-containing protein ajuba isoform 1
Function of the protein in oral and tooth development
Fatemifar et al.,(2013) conducted genome-wide association study and report genetic variants at 15 loci associated with primary tooth eruption at genome-wide significant levels, including 8 novel variants within or near the following genes: BMP4, CACNB2, CDON, CALU/OPN1SW, AJUBA/C14orf93, DLEU7, TEX14/RAD51C and ADK.
Dental and Oral Diseases
Protein Sequence
>NP_116265.1 LIM domain-containing protein ajuba isoform 1 [Homo sapiens]
MERLGEKASRLLEKFGRRKGESSRSGSDGTPGPGKGRLSGLGGPRKSGPRGATGGPGDEPLEPAREQGSL
DAERNQRGSFEAPRYEGSFPAGPPPTRALPLPQSLPPDFRLEPTAPALSPRSSFASSSASDASKPSSPRG
SLLLDGAGAGGAGGSRPCSNRTSGISMGYDQRHGSPLPAGPCLFGPPLAGAPAGYSPGGVPSAYPELHAA
LDRLYAQRPAGFGCQESRHSYPPALGSPGALAGAGVGAAGPLERRGAQPGRHSVTGYGDCAVGARYQDEL
TALLRLTVGTGGREAGARGEPSGIEPSGLEEPPGPFVPEAARARMREPEAREDYFGTCIKCNKGIYGQSN
ACQALDSLYHTQCFVCCSCGRTLRCKAFYSVNGSVYCEEDYLFSGFQEAAEKCCVCGHLILEKILQAMGK
SYHPGCFRCIVCNKCLDGIPFTVDFSNQVYCVTDYHKNYAPKCAACGQPILPSEGCEDIVRVISMDRDYH
FECYHCEDCRMQLSDEEGCCCFPLDGHLLCHGCHMQRLNARQPPANYI
Mutations
Related Literature
Fatemifar et al.,(2013). https://doi.org/10.1093/hmg/ddt231
