Bioinformatics Database
ADK: Adenosine kinase
3D Protein Structure Viewer
Cellular Process
Tooth Eruption
Gene Name
ADK: Adenosine kinase
Gene ID
132
Gene Sequence
General Description
This gene encodes an enzyme which catalyzes the transfer of the gamma-phosphate from ATP to adenosine, thereby serving as a regulator of concentrations of both extracellular adenosine and intracellular adenine nucleotides. Adenosine has widespread effects on the cardiovascular, nervous, respiratory, and immune systems and inhibitors of the enzyme could play an important pharmacological role in increasing intravascular adenosine concentrations and acting as anti-inflammatory agents.
Alternative titles; symbols
ADK
Chromosome
Chromosome 10
Cytogenetic location
10q22.2
Encoded Protein
Adenosine kinase isoform b
Function of the protein in oral and tooth development
Fatemifar et al.,(2013) conducted genome-wide association study and report genetic variants at 15 loci associated with primary tooth eruption at genome-wide significant levels, including 8 novel variants within or near the following genes: BMP4, CACNB2, CDON, CALU/OPN1SW, AJUBA, DLEU7, TEX14/RAD51C and ADK.
Dental and Oral Diseases
Protein Sequence
>NP_006712.2 adenosine kinase isoform b [Homo sapiens]
MAAAEEEPKPKKLKVEAPQALRENILFGMGNPLLDISAVVDKDFLDKYSLKPNDQILAEDKHKELFDELV
KKFKVEYHAGGSTQNSIKVAQWMIQQPHKAATFFGCIGIDKFGEILKRKAAEAHVDAHYYEQNEQPTGTC
AACITGDNRSLIANLAAANCYKKEKHLDLEKNWMLVEKARVCYIAGFFLTVSPESVLKVAHHASENNRIF
TLNLSAPFISQFYKESLMKVMPYVDILFGNETEAATFAREQGFETKDIKEIAKKTQALPKMNSKRQRIVI
FTQGRDDTIMATESEVTAFAVLDQDQKEIIDTNGAGDAFVGGFLSQLVSDKPLTECIRAGHYAASIIIRR
TGCTFPEKPDFH
Mutations
Related Literature
Fatemifar et al.,(2013). https://doi.org/10.1093/hmg/ddt231
