Bioinformatics Database
ACP4: Acid phosphatase 4 Enamel formation 93650
3D Protein Structure Viewer
Cellular Process
Enamel formation
Gene Name
ACP4: Acid phosphatase 4
Gene ID
93650
Gene Sequence
General Description
Acid phosphatases are enzymes capable of hydrolyzing orthophosphoric acid esters in an acid medium. This gene is up-regulated by androgens and is down-regulated by estrogens in the prostate cancer cell line. This gene exhibits a lower level of expression in testicular cancer tissues than in normal tissues. The protein encoded by this gene has structural similarity to prostatic and lysosomal acid phosphatases. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.
Alternative titles; symbols
Acid Phosphatase, Testicular; ACPT
Chromosome
Chromosome 19
Cytogenetic location
19q13.33
Encoded Protein
Testicular acid phosphatase precursor
Function of the protein in oral and tooth development
By immunohistochemical analysis, Seymen et al. (2016) showed that ACPT was localized in ameloblasts, follicular cells, odontoblasts, and osteoblasts, but not in maturation-stage ameloblasts, indicating that ACPT functions during the secretory stage of amelogenesis.
Choi et al. (2016) showed that ACPT induces odontoblast differentiation from dental mesenchyme during dentin formation and mineralization.
Dental and Oral Diseases
Amelogenesis imperfecta, type IJ
(OMIM ID: 606362)
Protein Sequence
>NP_149059.1 testicular acid phosphatase precursor [Homo sapiens]
MAGLGFWGHPAGPLLLLLLLVLPPRALPEGPLVFVALVFRHGDRAPLASYPMDPHKEVASTLWPRGLGQL
TTEGVRQQLELGRFLRSRYEAFLSPEYRREEVYIRSTDFDRTLESAQANLAGLFPEAAPGSPEARWRPIP
VHTVPVAEDKLLRFPMRSCPRYHELLREATEAAEYQEALEGWTGFLSRLENFTGLSLVGEPLRRAWKVLD
TLMCQQAHGLPLPAWASPDVLRTLAQISALDIGAHVGPPRAAEKAQLTGGILLNAILANFSRVQRLGLPL
KMVMYSAHDSTLLALQGALGLYDGHTPPYAACLGFEFRKHLGNPAKDGGNVTVSLFYRNDSAHLPLPLSL
PGCPAPCPLGRFYQLTAPARPPAHGVSCHGPYEAAIPPAPVVPLLAGAVAVLVALSLGLGLLAWRPGCLR
ALGGPV
Mutations
SER238LEU;
ARG111CYS;
ARG76CYS;
ALA128PRO;
GLU133LYS (Seymen et al., 2016)
Related Literature
Seymen et al., (2016): https://doi.org/10.1007/s00441-015-2310-9
