Bioinformatics Database
ITGB6: integrin subunit beta 6
Cellular Process
Enamel formation
Gene Name
ITGB6: integrin subunit beta 6
Gene ID
3694
Gene Sequence
General Description
This gene encodes a protein that is a member of the integrin superfamily. Members of this family are adhesion receptors that function in signaling from the extracellular matrix to the cell. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The encoded protein forms a dimer with an alpha v chain and this heterodimer can bind to ligands like fibronectin and transforming growth factor beta 1
Alternative titles; symbols
Chromosome
Chromosome 2
Cytogenetic location
2q24.2
Encoded Protein
Integrin beta-6 isoform a precursor
Function of the protein in oral and tooth development
Transforming growth factor-beta (TGF-β) is critical for cell proliferation and differentiation in dental pulp. Niwa et al. (2018) fouund that TGF-β1 is involved in a complicated dynamic interaction with matrix metalloproteinases (MMPs) and/or dentin sialophosphoprotein (DSPP)-derived proteins present in dental pulp, odontoblasts and dentin.
Dental and Oral Diseases
Amelogenesis imperfecta, type IH
(OMIM ID: 147558)
Protein Sequence
>NP_000879.2 integrin beta-6 isoform a precursor [Homo sapiens]
MGIELLCLFFLFLGRNDHVQGGCALGGAETCEDCLLIGPQCAWCAQENFTHPSGVGERCDTPANLLAKGC
QLNFIENPVSQVEILKNKPLSVGRQKNSSDIVQIAPQSLILKLRPGGAQTLQVHVRQTEDYPVDLYYLMD
LSASMDDDLNTIKELGSRLSKEMSKLTSNFRLGFGSFVEKPVSPFVKTTPEEIANPCSSIPYFCLPTFGF
KHILPLTNDAERFNEIVKNQKISANIDTPEGGFDAIMQAAVCKEKIGWRNDSLHLLVFVSDADSHFGMDS
KLAGIVIPNDGLCHLDSKNEYSMSTVLEYPTIGQLIDKLVQNNVLLIFAVTQEQVHLYENYAKLIPGATV
GLLQKDSGNILQLIISAYEELRSEVELEVLGDTEGLNLSFTAICNNGTLFQHQKKCSHMKVGDTASFSVT
VNIPHCERRSRHIIIKPVGLGDALELLVSPECNCDCQKEVEVNSSKCHHGNGSFQCGVCACHPGHMGPRC
ECGEDMLSTDSCKEAPDHPSCSGRGDCYCGQCICHLSPYGNIYGPYCQCDNFSCVRHKGLLCGGNGDCDC
GECVCRSGWTGEYCNCTTSTDSCVSEDGVLCSGRGDCVCGKCVCTNPGASGPTCERCPTCGDPCNSKRSC
IECHLSAAGQAREECVDKCKLAGATISEEEDFSKDGSVSCSLQGENECLITFLITTDNEGKTIIHSINEK
DCPKPPNIPMIMLGVSLAILLIGVVLLCIWKLLVSFHDRKEVAKFEAERSKAKWQTGTNPLYRGSTSTFK
NVTYKHREKQKVDLSTDC
Mutations
A143T: ala143-to-thr substitution,
H275Q: his275-to-gln substitution,
R616X: arg616-to-ter substitution,
P196T: pro196-to-thr substitution.
(Wang et al.,2014; Poulter et al., 2014)
Related Literature
Niwa et al., (2018): https://doi.org/10.1038/s41598-018-22823-7
Poulter et al., (2014): https://doi.org/10.1093/hmg/ddt616
Wang et al., (2014): https://doi.org/10.1093/hmg/ddt611
