Bioinformatics Database
CSF1: Colony stimulating factor 1
3D Protein Structure Viewer
Cellular Process
Tooth Eruption
Gene Name
CSF1: Colony stimulating factor 1
Gene ID
1435
Gene Sequence
General Description
The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of macrophages. The active form of the protein is found extracellularly as a disulfide-linked homodimer, and is thought to be produced by proteolytic cleavage of membrane-bound precursors. The encoded protein may be involved in development of the placenta.
Alternative titles; symbols
COLONY-STIMULATING FACTOR, MACROPHAGE-SPECIFIC; MCSF
Chromosome
Chromosome 1
Cytogenetic location
1p13.3
Encoded Protein
Macrophage colony-stimulating factor 1 isoform a precursor
Function of the protein in oral and tooth development
Nagahama et al., (1998) performed a study to the effect of CSF-1 in osteopetrotic (op/op) mice, which carry a mutation of colony-stimulating factor-1 (CSF-1). The results showed failure of bone resorption, lack of tooth eruption, and poor root formation in the mutant mice.
Van Wesenbeeck et al. (2002) identified the genetic lesion in the 'toothless' (tl) rat as a 10-bp insertion near the beginning of the open reading frame of the Csf1 gene, yielding a truncated, nonfunctional protein and an early stop codon.
Dental and Oral Diseases
Protein Sequence
>NP_000748.4 macrophage colony-stimulating factor 1 isoform a precursor [Homo sapiens]
MTAPGAAGRCPPTTWLGSLLLLVCLLASRSITEEVSEYCSHMIGSGHLQSLQRLIDSQMETSCQITFEFV
DQEQLKDPVCYLKKAFLLVQDIMEDTMRFRDNTPNAIAIVQLQELSLRLKSCFTKDYEEHDKACVRTFYE
TPLQLLEKVKNVFNETKNLLDKDWNIFSKNCNNSFAECSSQDVVTKPDCNCLYPKAIPSSDPASVSPHQP
LAPSMAPVAGLTWEDSEGTEGSSLLPGEQPLHTVDPGSAKQRPPRSTCQSFEPPETPVVKDSTIGGSPQP
RPSVGAFNPGMEDILDSAMGTNWVPEEASGEASEIPVPQGTELSPSRPGGGSMQTEPARPSNFLSASSPL
PASAKGQQPADVTGTALPRVGPVRPTGQDWNHTPQKTDHPSALLRDPPEPGSPRISSLRPQGLSNPSTLS
AQPQLSRSHSSGSVLPLGELEGRRSTRDRRSPAEPEGGPASEGAARPLPRFNSVPLTDTGHERQSEGSFS
PQLQESVFHLLVPSVILVLLAVGGLLFYRWRRRSHQEPQRADSPLEQPEGSPLTQDDRQVELPV
Mutations
Related Literature
Nagahama et al, (1998). https://doi.org/10.1002/(SICI)1097-0177(199801)211:1<52::AID-AJA5>3.0.CO;2-6
Van Wesenbeeck et al, (2002). https://doi.org/10.1073/pnas.202332999
